LncRNA-BLACAT1 Facilitates Proliferation, Migration and Aerobic Glycolysis of Pancreatic Cancer Cells by Repressing CDKN1C via EZH2-Induced H3K27me3

OBJECTIVE: To investigate the role of lncRNA-BLACAT1 in promoting H3K27 trimethylation of CDKN1C gene by recruiting EZH2 to regulate CCNE on glycolysis and mitochondrial oxidative phosphorylation of pancreatic cancer (PC) cells. METHODS: Following bioinformatic prediction, EZH2 and BLACAT1 in PC cel...

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Bibliographic Details
Published in:Front Oncol
Main Authors: Zhou, Xin, Gao, Wei, Hua, Huanhuan, Ji, Zhimin
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7538708/
https://ncbi.nlm.nih.gov/pubmed/33072570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.539805
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