A New lncRNA, APTR, Associates with and Represses the CDKN1A/p21 Promoter by Recruiting Polycomb Proteins

Long noncoding RNAs (lncRNAs) have emerged as a major regulator of cell physiology, but many of which have no known function. CDKN1A/p21 is an important inhibitor of the cell-cycle, regulator of the DNA damage response and effector of the tumor suppressor p53, playing a crucial role in tumor develop...

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Bibliografiske detaljer
Main Authors: Negishi, Masamitsu, Wongpalee, Somsakul P., Sarkar, Sukumar, Park, Jonghoon, Lee, Kyung Yong, Shibata, Yoshiyuki, Reon, Brian J., Abounader, Roger, Suzuki, Yutaka, Sugano, Sumio, Dutta, Anindya
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3991591/
https://ncbi.nlm.nih.gov/pubmed/24748121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095216
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