Diagnostic Test Criteria for HLA Genotyping to Prevent Drug Hypersensitivity Reactions: A Systematic Review of Actionable HLA Recommendations in CPIC and DPWG Guidelines

INTRODUCTION: Certain HLA variants are associated with an increased risk of hypersensitivity reactions to specific drugs. Both the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutch Pharmacogenetics Working Group (DPWG) have issued actionable HLA gene – drug interaction guideli...

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Udgivet i:Front Pharmacol
Main Authors: Manson, Lisanne E. N., Swen, Jesse J., Guchelaar, Henk-Jan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7538700/
https://ncbi.nlm.nih.gov/pubmed/33071783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.567048
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