CD44/HA signaling mediates acquired resistance to a PI3Kα inhibitor

Most luminal breast carcinomas (BrCas) bearing PIK3CA mutations initially respond to phosphoinositide-3-kinase (PI3K)-α inhibitors, but many eventually become resistant. The underlying mechanisms of this resistance remain obscure. In this work, we showed that a CD44(high) state due to aberrant isofo...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Yang, Cuixia, Sheng, Yumeng, Shi, Xiaoxing, Liu, Yiwen, He, Yiqing, Du, Yan, Zhang, Guoliang, Gao, Feng
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7538592/
https://ncbi.nlm.nih.gov/pubmed/33024087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03037-0
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