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CD44/HA signaling mediates acquired resistance to a PI3Kα inhibitor
Most luminal breast carcinomas (BrCas) bearing PIK3CA mutations initially respond to phosphoinositide-3-kinase (PI3K)-α inhibitors, but many eventually become resistant. The underlying mechanisms of this resistance remain obscure. In this work, we showed that a CD44(high) state due to aberrant isofo...
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| Publicat a: | Cell Death Dis |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7538592/ https://ncbi.nlm.nih.gov/pubmed/33024087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03037-0 |
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