Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death

Amyloid beta (Aβ) accumulates within neurons in the brains of early stage Alzheimer’s disease (AD) patients. However, the mechanism underlying its toxicity remains unclear. Here, a triple omics approach was used to integrate transcriptomic, proteomic, and metabolomic data collected from a nerve cell...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Huang, Ling, McClatchy, Daniel B., Maher, Pamela, Liang, Zhibin, Diedrich, Jolene K., Soriano-Castell, David, Goldberg, Joshua, Shokhirev, Maxim, Yates, John R., Schubert, David, Currais, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7538552/
https://ncbi.nlm.nih.gov/pubmed/33024077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03020-9
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