Deciphering and predicting CD4(+) T cell immunodominance of influenza virus hemagglutinin

The importance of CD4(+) T helper (Th) cells is well appreciated in view of their essential role in the elicitation of antibody and cytotoxic T cell responses. However, the mechanisms that determine the selection of immunodominant epitopes within complex protein antigens remain elusive. Here, we use...

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Vydáno v:J Exp Med
Hlavní autoři: Cassotta, Antonino, Paparoditis, Philipp, Geiger, Roger, Mettu, Ramgopal R., Landry, Samuel J., Donati, Alessia, Benevento, Marco, Foglierini, Mathilde, Lewis, David J.M., Lanzavecchia, Antonio, Sallusto, Federica
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7537397/
https://ncbi.nlm.nih.gov/pubmed/32644114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200206
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