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Human naive and memory CD4(+) T cell repertoires specific for naturally processed antigens analyzed using libraries of amplified T cells

The enormous diversity of the naive T cell repertoire is instrumental in generating an immune response to virtually any foreign antigen that can be processed into peptides that bind to MHC molecules. The low frequency of antigen-specific naive T cells, their high activation threshold, and the constr...

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Hlavní autoři: Geiger, Rebekka, Duhen, Thomas, Lanzavecchia, Antonio, Sallusto, Federica
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715094/
https://ncbi.nlm.nih.gov/pubmed/19564353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090504
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