Modeling the Role of a Flexible Loop and Active Site Side Chains in Hydride Transfer Catalyzed by Glycerol-3-phosphate Dehydrogenase

[Image: see text] Glycerol-3-phosphate dehydrogenase is a biomedically important enzyme that plays a crucial role in lipid biosynthesis. It is activated by a ligand-gated conformational change that is necessary for the enzyme to reach a catalytically competent conformation capable of efficient trans...

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Detalhes bibliográficos
Publicado no:ACS Catal
Main Authors: Mhashal, Anil R., Romero-Rivera, Adrian, Mydy, Lisa S., Cristobal, Judith R., Gulick, Andrew M., Richard, John P., Kamerlin, Shina C. L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536716/
https://ncbi.nlm.nih.gov/pubmed/33042609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.0c02757
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