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An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease

We previously reported a protective association between single nucleotide polymorphisms (SNPs; rs4415345G and rs4610776A alleles) of Paneth cell α-defensin-5 against acute graft-versus-host disease (aGVHD). Because dysbiosis has been associated with aGVHD, we hypothesized that these SNPs may have a...

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Vydáno v:Br J Haematol
Hlavní autoři: Rashidi, Armin, Herman, Adam, Gomes, Antonio LC, Peled, Jonathan U., Jenq, Robert R., Brereton, Daniel G., Staley, Christopher, Blazar, Bruce R., Weisdorf, Daniel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536617/
https://ncbi.nlm.nih.gov/pubmed/32086815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.16458
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