Enhanced asthma-related fibroblast to myofibroblast transition is the result of profibrotic TGF-β/Smad2/3 pathway intensification and antifibrotic TGF-β/Smad1/5/(8)9 pathway impairment

Airway remodelling with subepithelial fibrosis, which abolishes the physiological functions of the bronchial wall, is a major issue in bronchial asthma. Human bronchial fibroblasts (HBFs) derived from patients diagnosed with asthma display in vitro predestination towards TGF-β(1)-induced fibroblast-...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Wnuk, Dawid, Paw, Milena, Ryczek, Karolina, Bochenek, Grażyna, Sładek, Krzysztof, Madeja, Zbigniew, Michalik, Marta
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536388/
https://ncbi.nlm.nih.gov/pubmed/33020537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73473-7
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