Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting

Mitochondrial deregulation has gained increasing support as a pathological mechanism in Huntington’s disease (HD), a genetic-based neurodegenerative disorder caused by CAG expansion in the HTT gene. In this study, we thoroughly investigated mitochondrial-based mechanisms in HD patient-derived iPSC (...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Front Cell Dev Biol
Главные авторы: Lopes, Carla, Tang, Yang, Anjo, Sandra I., Manadas, Bruno, Onofre, Isabel, de Almeida, Luís P., Daley, George Q., Schlaeger, Thorsten M., Rego, Ana Cristina Carvalho
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2020
Предметы:
Cell and Developmental Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536317/
https://ncbi.nlm.nih.gov/pubmed/33072759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.576592
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы