Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting

Mitochondrial deregulation has gained increasing support as a pathological mechanism in Huntington’s disease (HD), a genetic-based neurodegenerative disorder caused by CAG expansion in the HTT gene. In this study, we thoroughly investigated mitochondrial-based mechanisms in HD patient-derived iPSC (...

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Publicat a:Front Cell Dev Biol
Autors principals: Lopes, Carla, Tang, Yang, Anjo, Sandra I., Manadas, Bruno, Onofre, Isabel, de Almeida, Luís P., Daley, George Q., Schlaeger, Thorsten M., Rego, Ana Cristina Carvalho
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Cell and Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536317/
https://ncbi.nlm.nih.gov/pubmed/33072759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.576592
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