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Truncation of Tau selectively facilitates its pathological activities
Neurofibrillary tangles of abnormally hyperphosphorylated Tau are a hallmark of Alzheimer's disease (AD) and related tauopathies. Tau is truncated at multiple sites by various proteases in AD brain. Although many studies have reported the effect of truncation on the aggregation of Tau, these st...
Guardado en:
| Publicado en: | J Biol Chem |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7535906/ https://ncbi.nlm.nih.gov/pubmed/32737201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012587 |
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