Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer’s Disease

Microtubule (MT) associated protein tau is abnormally hyperphosphorylated and aggregated into paired helical filaments (PHFs), which manifest as neurofibrillary tangles (NFTs) in the brains of individuals with Alzheimer’s disease (AD) and related tauopathies. Hyperphosphorylation and truncation of t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Aging Neurosci
Prif Awduron: Zhou, Yan, Shi, Jianhua, Chu, Dandan, Hu, Wen, Guan, Zongyu, Gong, Cheng-Xin, Iqbal, Khalid, Liu, Fei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2018
Pynciau:
Neuroscience
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5810298/
https://ncbi.nlm.nih.gov/pubmed/29472853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2018.00027
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