Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE

Hyperphosphorylation and dysregulation of exon 10 splicing of Tau are pivotally involved in pathogenesis of Alzheimer disease (AD) and/or other tauopathies. Alternative splicing of Tau exon 10, which encodes the second microtubule-binding repeat, generates Tau isoforms containing three and four micr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jin, Nana, Yin, Xiaomin, Gu, Jianlan, Zhang, Xinhua, Shi, Jianhua, Qian, Wei, Ji, Yuhua, Cao, Maohong, Gu, Xiaosong, Ding, Fei, Iqbal, Khalid, Gong, Cheng-Xin, Liu, Fei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4463463/
https://ncbi.nlm.nih.gov/pubmed/25918155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.645507
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