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Nociceptors protect sickle cell disease mice from vaso-occlusive episodes and chronic organ damage

Sickle cell disease (SCD) is a common hereditary hematologic disorder. SCD patients suffer from acute vaso-occlusive episodes (VOEs), chronic organ damage, and premature death, with few therapeutic options. Although severe pain is a major clinical manifestation of SCD, it remains unknown whether noc...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Xu, Chunliang, Gulinello, Maria, Frenette, Paul S.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534906/
https://ncbi.nlm.nih.gov/pubmed/33045060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200065
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