TET2 promotes anti‐tumor immunity by governing G‐MDSCs and CD8(+) T‐cell numbers

The host immune response is a fundamental mechanism for attenuating cancer progression. Here we report a role for the DNA demethylase and tumor suppressor TET2 in host anti‐tumor immunity. Deletion of Tet2 in mice elevates IL‐6 levels upon tumor challenge. Elevated IL‐6 stimulates immunosuppressive...

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Vydáno v:EMBO Rep
Hlavní autoři: Li, Shuangqi, Feng, Jiuxing, Wu, Feizhen, Cai, Jiabin, Zhang, Xinyu, Wang, Haikun, Fetahu, Irfete S, Iwanicki, Isabella, Ma, Dingailu, Hu, Tao, Liu, Hang, Wang, Bingjie, Shi, Guoming, Tan, Li, Shi, Yujiang Geno
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534639/
https://ncbi.nlm.nih.gov/pubmed/32929842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949425
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