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TET2 promotes anti‐tumor immunity by governing G‐MDSCs and CD8(+) T‐cell numbers
The host immune response is a fundamental mechanism for attenuating cancer progression. Here we report a role for the DNA demethylase and tumor suppressor TET2 in host anti‐tumor immunity. Deletion of Tet2 in mice elevates IL‐6 levels upon tumor challenge. Elevated IL‐6 stimulates immunosuppressive...
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| Veröffentlicht in: | EMBO Rep |
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| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7534639/ https://ncbi.nlm.nih.gov/pubmed/32929842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949425 |
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