Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice

Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). Loss of PGRN leads to lysosome dysfunction during aging. TMEM106B, a gene encoding a lysosomal membrane protein, is the main risk factor for FTLD with PGRN haploinsufficiency. But how TMEM106B af...

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Pubblicato in:EMBO Rep
Autori principali: Feng, Tuancheng, Mai, Shuyi, Roscoe, Jenn Marie, Sheng, Rory R, Ullah, Mohammed, Zhang, Junke, Katz, Isabel Iscol, Yu, Haiyuan, Xiong, Wenjun, Hu, Fenghua
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534636/
https://ncbi.nlm.nih.gov/pubmed/32852886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202050219
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