Short Vi-polysaccharide abrogates T-independent immune response and hyporesponsiveness elicited by long Vi-CRM(197) conjugate vaccine

Polysaccharide-protein conjugates have been developed to overcome the T-independent response, hyporesponsiveness to repeated vaccination, and poor immunogenicity in infants of polysaccharides. To address the impact of polysaccharide length, typhoid conjugates made with short- and long-chain fraction...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Micoli, Francesca, Bjarnarson, Stefania P., Arcuri, Melissa, Aradottir Pind, Audur Anna, Magnusdottir, Gudbjorg J., Necchi, Francesca, Di Benedetto, Roberta, Carducci, Martina, Schiavo, Fabiola, Giannelli, Carlo, Pisoni, Ivan, Martin, Laura B., Del Giudice, Giuseppe, MacLennan, Calman A., Rappuoli, Rino, Jonsdottir, Ingileif, Saul, Allan
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2020
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533886/
https://ncbi.nlm.nih.gov/pubmed/32900928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005857117
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