Pneumococcal Polysaccharide Abrogates Conjugate-Induced Germinal Center Reaction and Depletes Antibody Secreting Cell Pool, Causing Hyporesponsiveness

BACKGROUND: Plain pneumococcal polysaccharide (PPS) booster administered during second year of life has been shown to cause hyporesponsiveness. We assessed the effects of PPS booster on splenic memory B cell responses and persistence of PPS-specific long-lived plasma cells in the bone marrow (BM). M...

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Autores principales: Bjarnarson, Stefania P., Benonisson, Hreinn, Del Giudice, Giuseppe, Jonsdottir, Ingileif
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771989/
https://ncbi.nlm.nih.gov/pubmed/24069152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072588
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