Short Vi-polysaccharide abrogates T-independent immune response and hyporesponsiveness elicited by long Vi-CRM(197) conjugate vaccine

Polysaccharide-protein conjugates have been developed to overcome the T-independent response, hyporesponsiveness to repeated vaccination, and poor immunogenicity in infants of polysaccharides. To address the impact of polysaccharide length, typhoid conjugates made with short- and long-chain fraction...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Micoli, Francesca, Bjarnarson, Stefania P., Arcuri, Melissa, Aradottir Pind, Audur Anna, Magnusdottir, Gudbjorg J., Necchi, Francesca, Di Benedetto, Roberta, Carducci, Martina, Schiavo, Fabiola, Giannelli, Carlo, Pisoni, Ivan, Martin, Laura B., Del Giudice, Giuseppe, MacLennan, Calman A., Rappuoli, Rino, Jonsdottir, Ingileif, Saul, Allan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533886/
https://ncbi.nlm.nih.gov/pubmed/32900928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005857117
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