Short Vi-polysaccharide abrogates T-independent immune response and hyporesponsiveness elicited by long Vi-CRM(197) conjugate vaccine

Polysaccharide-protein conjugates have been developed to overcome the T-independent response, hyporesponsiveness to repeated vaccination, and poor immunogenicity in infants of polysaccharides. To address the impact of polysaccharide length, typhoid conjugates made with short- and long-chain fraction...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Proc Natl Acad Sci U S A
Κύριοι συγγραφείς: Micoli, Francesca, Bjarnarson, Stefania P., Arcuri, Melissa, Aradottir Pind, Audur Anna, Magnusdottir, Gudbjorg J., Necchi, Francesca, Di Benedetto, Roberta, Carducci, Martina, Schiavo, Fabiola, Giannelli, Carlo, Pisoni, Ivan, Martin, Laura B., Del Giudice, Giuseppe, MacLennan, Calman A., Rappuoli, Rino, Jonsdottir, Ingileif, Saul, Allan
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2020
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533886/
https://ncbi.nlm.nih.gov/pubmed/32900928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005857117
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