Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx)

The relationship between oxidative stress and cardiac stiffness is thought to involve modifications to the giant muscle protein titin, which in turn can determine the progression of heart disease. In vitro studies have shown that S-glutathionylation and disulfide bonding of titin fragments could alt...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Loescher, Christine M., Breitkreuz, Martin, Li, Yong, Nickel, Alexander, Unger, Andreas, Dietl, Alexander, Schmidt, Andreas, Mohamed, Belal A., Kötter, Sebastian, Schmitt, Joachim P., Krüger, Marcus, Krüger, Martina, Toischer, Karl, Maack, Christoph, Leichert, Lars I., Hamdani, Nazha, Linke, Wolfgang A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533878/
https://ncbi.nlm.nih.gov/pubmed/32929035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004900117
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