Sildenafil and BNP Acutely Phosphorylate Titin and Improve Diastolic Distensibility in Vivo

BACKGROUND: In vitro studies suggest that phosphorylation of titin reduces myocyte/myofiber stiffness. Titin can be phosphorylated by cGMP activated protein kinase (PKG). Intracellular cGMP production is stimulated by B-type natriuretic peptide (BNP) and degraded by phosphodiesterases (PDE) includin...

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Bibliografiske detaljer
Main Authors: Bishu, Kalkidan, Hamdani, Nazha, Mohammed, Selma F., Kruger, Martina, Ohtani, Tomohito, Ogut, Ozgur, Brozovich, Frank V., Burnett, John C., Linke, Wolfgang A., Redfield, Margaret M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412357/
https://ncbi.nlm.nih.gov/pubmed/22144574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.048520
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