Sildenafil and BNP Acutely Phosphorylate Titin and Improve Diastolic Distensibility in Vivo

BACKGROUND: In vitro studies suggest that phosphorylation of titin reduces myocyte/myofiber stiffness. Titin can be phosphorylated by cGMP activated protein kinase (PKG). Intracellular cGMP production is stimulated by B-type natriuretic peptide (BNP) and degraded by phosphodiesterases (PDE) includin...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Bishu, Kalkidan, Hamdani, Nazha, Mohammed, Selma F., Kruger, Martina, Ohtani, Tomohito, Ogut, Ozgur, Brozovich, Frank V., Burnett, John C., Linke, Wolfgang A., Redfield, Margaret M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412357/
https://ncbi.nlm.nih.gov/pubmed/22144574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.048520
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados