Anti-Remodeling Effects of Rapamycin in Experimental Heart Failure: Dose Response and Interaction with Angiotensin Receptor Blockade

While neurohumoral antagonists improve outcomes in heart failure (HF), cardiac remodeling and dysfunction progress and outcomes remain poor. Therapies superior or additive to standard HF therapy are needed. Pharmacologic mTOR inhibition by rapamycin attenuated adverse cardiac remodeling and dysfunct...

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Detalhes bibliográficos
Main Authors: Bishu, Kalkidan, Ogut, Ozgur, Kushwaha, Sudhir, Mohammed, Selma F., Ohtani, Tomohito, Xu, Xiaolei, Brozovich, Frank V., Redfield, Margaret M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849273/
https://ncbi.nlm.nih.gov/pubmed/24312548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081325
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