Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection

Microglia are considered both pathogenic and protective during recovery from demyelination, but their precise role remains ill defined. Here, using an inhibitor of colony stimulating factor 1 receptor (CSF1R), PLX5622, and mice infected with a neurotropic coronavirus (mouse hepatitis virus [MHV], st...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sariol, Alan, Mackin, Samantha, Allred, Merri-Grace, Ma, Chen, Zhou, Yu, Zhang, Qinran, Zou, Xiufen, Abrahante, Juan E., Meyerholz, David K., Perlman, Stanley
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533697/
https://ncbi.nlm.nih.gov/pubmed/32929007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007814117
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