Hair cell α9α10 nicotinic acetylcholine receptor functional expression regulated by ligand binding and deafness gene products

Auditory hair cells receive olivocochlear efferent innervation, which refines tonotopic mapping, improves sound discrimination, and mitigates acoustic trauma. The olivocochlear synapse involves α9α10 nicotinic acetylcholine receptors (nAChRs), which assemble in hair cells only coincident with cholin...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Gu, Shenyan, Knowland, Daniel, Matta, Jose A., O’Carroll, Min L., Davini, Weston B., Dhara, Madhurima, Kweon, Hae-Jin, Bredt, David S.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533656/
https://ncbi.nlm.nih.gov/pubmed/32929005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013762117
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