Hair cell α9α10 nicotinic acetylcholine receptor functional expression regulated by ligand binding and deafness gene products

Auditory hair cells receive olivocochlear efferent innervation, which refines tonotopic mapping, improves sound discrimination, and mitigates acoustic trauma. The olivocochlear synapse involves α9α10 nicotinic acetylcholine receptors (nAChRs), which assemble in hair cells only coincident with cholin...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Gu, Shenyan, Knowland, Daniel, Matta, Jose A., O’Carroll, Min L., Davini, Weston B., Dhara, Madhurima, Kweon, Hae-Jin, Bredt, David S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2020
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533656/
https://ncbi.nlm.nih.gov/pubmed/32929005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013762117
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