The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration

mRNA-lipoplex vaccines are currently being explored in phase II clinical trials for the treatment of patients with advanced solid tumors. Mechanistically, these mRNA-lipoplex vaccines are characterized by the induction of type I interferon (IFN) centered innate responses. Earlier studies have identi...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther Nucleic Acids
Hauptverfasser: Van Hoecke, Lien, Roose, Kenny, Ballegeer, Marlies, Zhong, Zifu, Sanders, Niek N., De Koker, Stefaan, Saelens, Xavier, Van Lint, Sandra
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533292/
https://ncbi.nlm.nih.gov/pubmed/33230442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.09.004
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