Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones

There is a pressing need to improve the efficiency of drug development, and nowhere is that need more clear than in the case of neglected diseases like malaria. The peculiarities of pyrimidine metabolism in Plasmodium species make inhibition of dihydroorotate dehydrogenase (DHODH) an attractive targ...

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Veröffentlicht in:J Comput Aided Mol Des
Hauptverfasser: Clark, Robert D., Morris, Denise N., Chinigo, Gary, Lawless, Michael S., Prudhomme, Jacques, Le Roch, Karine G., Lafuente, Maria José, Ferrer, Santiago, Gamo, Francisco Javier, Gadwood, Robert, Woltosz, Walter S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533260/
https://ncbi.nlm.nih.gov/pubmed/32833084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-020-00333-x
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