Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones

There is a pressing need to improve the efficiency of drug development, and nowhere is that need more clear than in the case of neglected diseases like malaria. The peculiarities of pyrimidine metabolism in Plasmodium species make inhibition of dihydroorotate dehydrogenase (DHODH) an attractive targ...

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Bibliografske podrobnosti
izdano v:J Comput Aided Mol Des
Main Authors: Clark, Robert D., Morris, Denise N., Chinigo, Gary, Lawless, Michael S., Prudhomme, Jacques, Le Roch, Karine G., Lafuente, Maria José, Ferrer, Santiago, Gamo, Francisco Javier, Gadwood, Robert, Woltosz, Walter S.
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533260/
https://ncbi.nlm.nih.gov/pubmed/32833084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-020-00333-x
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