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Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics

The exchange proteins activated by cAMP (EPAC) are implicated in a large variety of physiological processes and they are considered as promising targets for a wide range of therapeutic applications. Several recent reports provided evidence for the therapeutic effectiveness of the inhibiting EPAC1 ac...

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Bibliografske podrobnosti
izdano v:J Comput Aided Mol Des
Main Authors: Bufano, Marianna, Laudette, Marion, Blondeau, Jean-Paul, Lezoualc’h, Frank, Nalli, Marianna, Silvestri, Romano, Brancale, Andrea, Coluccia, Antonio
Format: Artigo
Jezik:Inglês
Izdano: Springer International Publishing 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533256/
https://ncbi.nlm.nih.gov/pubmed/32700175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-020-00332-y
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