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Improving transgene expression and CRISPR‐Cas9 efficiency with molecular engineering‐based molecules

As a novel and robust gene‐editing tool, the Clustered Regularly Interspaced Short Palindromic Repeats CRISPR‐associated protein 9 (CRISPR‐Cas9) system has revolutionized gene therapy. Plasmid vector delivery is the most commonly used method for integrating the CRISPR‐Cas9 system into cells. However...

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Detalhes bibliográficos
Publicado no:Clin Transl Med
Main Authors: Zhan, Hengji, Li, Aolin, Cai, Zhiming, Huang, Weiren, Liu, Yuchen
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533053/
https://ncbi.nlm.nih.gov/pubmed/33135339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.194
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