Pharmacological inhibition of mTORC1 increases CCKBR-specific tumor uptake of radiolabeled minigastrin analogue [(177)Lu]Lu-PP-F11N

Rationale: A high tumor-to-healthy-tissue uptake ratio of radiolabeled ligands is an essential prerequisite for safe and effective peptide receptor radionuclide therapy (PRRT). In the present study, we searched for novel opportunities to increase tumor-specific uptake of the radiolabeled minigastrin...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Grzmil, Michal, Qin, Yun, Schleuniger, Carina, Frank, Stephan, Imobersteg, Stefan, Blanc, Alain, Spillmann, Martin, Berger, Philipp, Schibli, Roger, Behe, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7532663/
https://ncbi.nlm.nih.gov/pubmed/33042258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.45440
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