Pharmacological inhibition of mTORC1 increases CCKBR-specific tumor uptake of radiolabeled minigastrin analogue [(177)Lu]Lu-PP-F11N

Rationale: A high tumor-to-healthy-tissue uptake ratio of radiolabeled ligands is an essential prerequisite for safe and effective peptide receptor radionuclide therapy (PRRT). In the present study, we searched for novel opportunities to increase tumor-specific uptake of the radiolabeled minigastrin...

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Bibliographic Details
Published in:Theranostics
Main Authors: Grzmil, Michal, Qin, Yun, Schleuniger, Carina, Frank, Stephan, Imobersteg, Stefan, Blanc, Alain, Spillmann, Martin, Berger, Philipp, Schibli, Roger, Behe, Martin
Format: Artigo
Language:Inglês
Published: Ivyspring International Publisher 2020
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7532663/
https://ncbi.nlm.nih.gov/pubmed/33042258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.45440
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