A Phase 1 and pharmacokinetic study evaluating daily or weekly schedules of the humanized anti-GD2 antibody hu14.18K322A in recurrent/refractory solid tumors

Hu14.18K322A is a humanized anti-GD2 monoclonal antibody with a single point mutation that reduces complement-mediated cytotoxicity, with a maximum tolerated dose (MTD) of 60 mg/m(2) daily for 4 days in children with recurrent/refractory neuroblastoma. We report additional results of a Phase 1 trial...

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Publicat a:MAbs
Autors principals: Bishop, Michael W., Hutson, Paul R., Hank, Jacquelyn A., Sondel, Paul M., Furman, Wayne L., Meagher, Michael M., Navid, Fariba, Santana, Victor M.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2020
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Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531516/
https://ncbi.nlm.nih.gov/pubmed/32643524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2020.1773751
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