Chronic lymphocytic leukemia (CLL) risk is mediated by multiple enhancer variants within CLL risk loci

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries. It has a strong genetic basis, showing a ~ 8-fold increased risk of CLL in first-degree relatives. Genome-wide association studies (GWAS) have identified 41 risk variants across 41 loci. However, for a majorit...

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Publicado en:Hum Mol Genet
Autores principales: Yan, Huihuang, Tian, Shulan, Kleinstern, Geffen, Wang, Zhiquan, Lee, Jeong-Heon, Boddicker, Nicholas J, Cerhan, James R, Kay, Neil E, Braggio, Esteban, Slager, Susan L
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
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General Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7530532/
https://ncbi.nlm.nih.gov/pubmed/32744316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa165
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