Tumor mutational load predicts time to first treatment in chronic lymphocytic leukemia (CLL) and monoclonal B-cell lymphocytosis beyond the CLL international prognostic index

Next-generation sequencing identified ~60 genes recurrently mutated in chronic lymphocytic leukemia (CLL). We examined the additive prognostic value of the total number of recurrently mutated CLL genes [i.e., tumor mutational load (TML)] or the individually mutated genes beyond the CLL international...

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Veröffentlicht in:Am J Hematol
Hauptverfasser: Kleinstern, Geffen, O’Brien, Daniel R., Li, Xing, Tian, Shulan, Kabat, Brian F., Rabe, Kari G., Norman, Aaron D., Yan, Huihuang, Vachon, Celine M., Boddicker, Nicholas J., Call, Timothy G., Parikh, Sameer A., Bruins, Laura, de Campos, Cecilia Bonolo, Leis, Jose F., Shanafelt, Tait D., Ding, Wei, Cerhan, James R., Kay, Neil E., Slager, Susan L., Braggio, Esteban
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7409825/
https://ncbi.nlm.nih.gov/pubmed/32279347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.25831
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