COMT Val158Met Genotype Alters the Effects of Methamphetamine Dependence on Dopamine and Dopamine-related Executive Function: Preliminary Findings

The Met allele of the COMT Val158Met polymorphism slows metabolism and increases bioavailability of dopamine (DA) in the prefrontal cortex compared to the Val allele. Healthy Met-carriers outperform Val-carriers on executive function (EF) tests, yet this ‘advantage’ disappears in methamphetamine (ME...

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Vydáno v:Psychiatry Res
Hlavní autoři: Saloner, Rowan, Cherner, Mariana, Sundermann, Erin E., Watson, Caitlin Wei-Ming, Iudicello, Jennifer E., Letendre, Scott L., Kumar, Adarsh, Ellis, Ronald J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7530039/
https://ncbi.nlm.nih.gov/pubmed/32739643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.psychres.2020.113269
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