Adverse Effect of Catechol-O-Methyltransferase (COMT) Val158Met Met/Met Genotype in Methamphetamine-related Executive Dysfunction

INTRODUCTION: The Val allele of the Val158Met single-nucleotide polymorphism of the catechol-o-methyltransferase gene (COMT) confers greater catabolism of dopamine (DA) in the prefrontal cortex (PFC) than the Met allele. Met/Met homozygotes typically outperform Val-carriers on tests of executive fun...

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Pubblicato in:Addict Behav
Autori principali: Cherner, Mariana, Watson, Caitlin W-M., Saloner, Rowan, Halpin, Laura, Minassian, Arpi, Murray, Sarah S., Vaida, Florin, Bousman, Chad, Everall, Ian
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6733518/
https://ncbi.nlm.nih.gov/pubmed/31301644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addbeh.2019.06.012
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