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COMT Val158Met Polymorphism, Cardiometabolic Risk, and Nadir CD4 Synergistically Increase Risk for Neurocognitive Impairment in Men Living with HIV

OBJECTIVE: The Val allele of the Val158Met single-nucleotide polymorphism of the catechol-o-methyltransferase gene (COMT) results in faster metabolism and reduced bioavailability of dopamine (DA). Among persons living with HIV (PLWH), Val carriers display neurocognitive deficits relative to Met carr...

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Detalhes bibliográficos
Publicado no:J Acquir Immune Defic Syndr
Main Authors: Saloner, Rowan, Marquine, Maria J., Sundermann, Erin E., Hong, Suzi, McCutchan, J. Allen, Ellis, Ronald J., Heaton, Robert K., Grant, Igor, Cherner, Mariana
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625879/
https://ncbi.nlm.nih.gov/pubmed/31107306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0000000000002083
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