Fitness Landscape of Clonal Hematopoiesis Under Selective Pressure of Immune Checkpoint Blockade

PURPOSE: Conventional cytotoxic therapies increase the risk of clonal hematopoiesis and select for TP53-mutant clones, which carry a high risk for transformation to therapy-related myelodysplastic neoplasms. In contrast, the effect of immune checkpoint blockade (ICB) on clonal hematopoiesis is unkno...

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Pubblicato in:JCO Precis Oncol
Autori principali: Miller, Peter G., Gibson, Christopher J., Mehta, Arnav, Sperling, Adam S., Frederick, Dennie T., Manos, Michael P., Miao, Benchun, Hacohen, Nir, Hodi, F. Stephen, Boland, Genevieve M., Ebert, Benjamin L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2020
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ORIGINAL REPORTS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529531/
https://ncbi.nlm.nih.gov/pubmed/33015529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00186
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