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Fitness Landscape of Clonal Hematopoiesis Under Selective Pressure of Immune Checkpoint Blockade
PURPOSE: Conventional cytotoxic therapies increase the risk of clonal hematopoiesis and select for TP53-mutant clones, which carry a high risk for transformation to therapy-related myelodysplastic neoplasms. In contrast, the effect of immune checkpoint blockade (ICB) on clonal hematopoiesis is unkno...
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| Publicado no: | JCO Precis Oncol |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Clinical Oncology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7529531/ https://ncbi.nlm.nih.gov/pubmed/33015529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00186 |
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