Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

The umbilical artery lumen closes rapidly at birth, preventing neonatal blood loss, whereas the umbilical vein remains patent longer. Here, analysis of umbilical cords from humans and other mammals identified differential arterial-venous proteoglycan dynamics as a determinant of these contrasting va...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Nandadasa, Sumeda, Szafron, Jason M, Pathak, Vai, Murtada, Sae-Il, Kraft, Caroline M, O'Donnell, Anna, Norvik, Christian, Hughes, Clare, Caterson, Bruce, Domowicz, Miriam S, Schwartz, Nancy B, Tran-Lundmark, Karin, Veigl, Martina, Sedwick, David, Philipson, Elliot H, Humphrey, Jay D, Apte, Suneel S
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Computational and Systems Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529456/
https://ncbi.nlm.nih.gov/pubmed/32909945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60683
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