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Characterization of t-loop formation by TRF2
T-loops are thought to hide telomeres from DNA damage signaling and DSB repair pathways. T-loop formation requires the shelterin component TRF2, which represses ATM signaling and NHEJ. Here we establish that TRF2 alone, in the absence of other shelterin proteins can form t-loops. Mouse and human cel...
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| Publicado no: | Nucleus |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7529409/ https://ncbi.nlm.nih.gov/pubmed/32564646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2020.1783782 |
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