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Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice

Cognitive decline with age is a harmful process that can reduce quality of life. Multiple factors have been established to contribute to cognitive decline, but the overall etiology remains unknown. Here, we hypothesized that cognitive dysfunction is mediated, in part, by increased levels of inflamma...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Lipid Res
Prif Awduron: Parks, Eileen E., Logan, Sreemathi, Yeganeh, Alexander, Farley, Julie A., Owen, Daniel B., Sonntag, William E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529050/
https://ncbi.nlm.nih.gov/pubmed/32669383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA119000479
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