Tumor quiescence: elevating SOX2 in diverse tumor cell types downregulates a broad spectrum of the cell cycle machinery and inhibits tumor growth

BACKGROUND: Quiescent tumor cells pose a major clinical challenge due to their ability to resist conventional chemotherapies and to drive tumor recurrence. Understanding the molecular mechanisms that promote quiescence of tumor cells could help identify therapies to eliminate these cells. Significan...

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Detaylı Bibliyografya
Yayımlandı:BMC Cancer
Asıl Yazarlar: Metz, Ethan P., Wuebben, Erin L., Wilder, Phillip J., Cox, Jesse L., Datta, Kaustubh, Coulter, Donald, Rizzino, Angie
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7528478/
https://ncbi.nlm.nih.gov/pubmed/32998722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07370-7
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