Tumor quiescence: elevating SOX2 in diverse tumor cell types downregulates a broad spectrum of the cell cycle machinery and inhibits tumor growth

BACKGROUND: Quiescent tumor cells pose a major clinical challenge due to their ability to resist conventional chemotherapies and to drive tumor recurrence. Understanding the molecular mechanisms that promote quiescence of tumor cells could help identify therapies to eliminate these cells. Significan...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Metz, Ethan P., Wuebben, Erin L., Wilder, Phillip J., Cox, Jesse L., Datta, Kaustubh, Coulter, Donald, Rizzino, Angie
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7528478/
https://ncbi.nlm.nih.gov/pubmed/32998722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07370-7
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