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Enhancement of trans-cleavage activity of Cas12a with engineered crRNA enables amplified nucleic acid detection
The CRISPR-Cas12a RNA-guided complexes have tremendous potential for nucleic acid detection but are limited to the picomolar detection limit without an amplification step. Here, we develop a platform with engineered crRNAs and optimized conditions that enabled us to detect various clinically relevan...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7528031/ https://ncbi.nlm.nih.gov/pubmed/32999292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18615-1 |
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