Activation of 4-1BBL(+) B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma

Immunotherapy has revolutionized the treatment of many tumors. However, most glioblastoma (GBM) patients have not, so far, benefited from such successes. With the goal of exploring ways to boost anti-GBM immunity, we developed a B cell–based vaccine (B(Vax)) that consists of 4-1BBL(+) B cells activa...

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Vydáno v:J Exp Med
Hlavní autoři: Lee-Chang, Catalina, Miska, Jason, Hou, David, Rashidi, Aida, Zhang, Peng, Burga, Rachel A., Jusué-Torres, Ignacio, Xiao, Ting, Arrieta, Victor A., Zhang, Daniel Y., Lopez-Rosas, Aurora, Han, Yu, Sonabend, Adam M., Horbinski, Craig M., Stupp, Roger, Balyasnikova, Irina V., Lesniak, Maciej S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527974/
https://ncbi.nlm.nih.gov/pubmed/32991668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200913
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